抗精神病药物问世已20余年,对其副作用的认识逐渐加深,自1960年以来,法语文献中曾屡次报道过一种以发热、缄默少动、肌肉僵直、震颤、咽下困难、多汗、脉搏加快、血压波动等锥体外系和植物神经症状为主的症候群,严重时类似脑炎或急性致死性紧张症,可导致死亡,故此称为“恶性”症候群[Syndrome(Neuro-Vegetatif)malin]。英、日文献中有少 Antipsychotic drugs have been around for more than 20 years and their side effects have been gradually deepened. Since 1960, French literature has repeatedly reported a fever, silent, stiff muscles, tremor, dysphagia, hyperhidrosis, pulse Syndrome (Neuro-Vegetatif) malin] syndromes such as accelerated exacerbation of blood pressure and other extrapyramidal and autonomic symptoms, and serious encephalitis or acute lethal stress disorder may lead to death. There is little literature in English and Japanese