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THE mechanism of the action of the classic platinum antitumor drugs can be interpreted accord-ing to their bidentate, bifunctional interaction with the DNA of the tumor cell, resulting in in-hibition of the DNA replication. Recently, it was found that a new class of compounds withthe general formula cis-[Pt(NH_3)_2(N-het)Cl]Cl(N-het is a heteroaromatic N-base like pyri-dine) show effective antitumor activities. However, two possible mechanisms of action were
THE mechanism of the action of the classic platinum antitumor drugs can be rendered accord-ing to their bidentate, bifunctional interaction with the DNA of the tumor cell, resulting in in-hibition of the DNA replication. Recently, it was found that a new class of compounds with the general formula cis- [Pt (NH_3) _2 (N-het) Cl] Cl (N-het is a heteroaromatic N-base like pyri-dine) show effective antitumor activities. However, two possible mechanisms of action were