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尼伐地平(nilvadipine)是一个新的二氢吡啶类钙拮抗剂,对血管平滑肌的作用大于对心肌组织或窦房结的影响。它选择性扩张脏器尤其是冠脉和脑动脉血管。 7例慢性脑梗塞,口服尼伐地平4mg前后,以~(133)氙吸入法测定局部脑血流(rCBF)。对照组为8例轻度慢性脑血管疾病。口服单剂尼伐地平4mg后1小时,rCBF增加幅度明显大于对照组(p<0.01)。病侧大脑半球rCBF由每分钟42.3±18.4增至49.9±13.9 ml/100g,净增22,7±19.4％(p<0.05),健侧rCBF的变化则不明显;以
Nilvadipine is a new dihydropyridine calcium antagonist that exerts a greater effect on vascular smooth muscle than myocardial or sinoatrial node. It selectively expand organs especially coronary and cerebral arteries. Local cerebral blood flow (rCBF) was measured in seven patients with chronic cerebral infarction and before and after oral administration of nilvadipine by ~ (133) xenon inhalation. The control group was 8 cases of mild chronic cerebrovascular disease. One hour after oral administration of 4 mg of nilvadipine, the increase of rCBF was significantly greater than that of the control group (p <0.01). The rCBF increased from 42.3 ± 18.4 to 49.9 ± 13.9 ml / 100g per minute, with a net increase of 22.7 ± 19.4% (p <0.05), while the change of rCBF in the contralateral hemisphere was not obvious.