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目的:通过实体瘤体外药敏试验以期指导食管癌术后化疗方案的选择,实现食管癌化疗个体化用药。方法:采用TECIA法对319例肿瘤组织标本进行体外组织培养,并用常见九种化疗药物进行药物敏感性试验,根据试验结果选用化疗方案进行术后辅助化疗。结果:319份标本对常见化疗药高敏感占2.4%,中敏感占48.6%;传统化疗方案药物部分呈现低度敏感,甚至耐药现象;根据药敏结果选用中、高敏感药物进行术后化疗其5年生存期明显延长,复发率降低。结论:肿瘤药物敏感试验对指导患者的个体化治疗具有重要的价值。
OBJECTIVE: To guide the selection of postoperative chemotherapeutic regimens for esophageal cancer through solid drug susceptibility testing in vitro to achieve individualized chemotherapy of esophageal cancer. Methods: Tissue culture was performed in 319 cases of tumor tissue by TECIA method, and drug susceptibility test was carried out with nine common chemotherapeutics. According to the results of the experiment, the chemotherapy regimen was used for postoperative adjuvant chemotherapy. Results: 319 specimens were sensitive to common chemotherapeutic drugs (2.4%) and moderately sensitive (48.6%). The drugs in traditional chemotherapy regimens showed low sensitivity and even drug resistance. According to the results of drug sensitivity, moderate and high sensitive drugs were used for postoperative chemotherapy The 5-year survival was significantly longer, the recurrence rate decreased. Conclusion: Tumor drug sensitivity test is of great value in guiding the individualized treatment of patients.