论文部分内容阅读
合成了7个大黄素季铵盐、2个芦荟大黄素季铵盐、1个水溶性大黄素季铵盐和1个α-萘酚醌苯基甲烷季铵盐化合物,并测试了其抗癌活性.含有1条长碳链的大黄素季铵盐的抗癌活性很低,但是含有2条长碳链的大黄素和芦荟大黄素季铵盐的抗癌活性较好.用亲水性的长链替代季铵盐中亲脂性的长碳链会导致大黄素季铵盐失去抗癌活性.α-萘酚醌苯基甲烷季铵盐显示了中等的抗癌活性,表明在具有电子传递能力的分子中引入亲脂性的长碳链季铵盐可以增加其抗癌活性.
Seven emodin quaternary ammonium salts, two aloe-emodin quaternary ammonium salts, one water-soluble emodin quaternary ammonium salt, and one α-naphthoquinone phenylmethane quaternary ammonium salt compound were synthesized and tested for anti-cancer Activity of a long carbon chain containing emodin quaternary ammonium anticancer activity is very low, but contains two long carbon chains of emodin and aloe-emodin Quaternary ammonium salt better anti-cancer activity with hydrophilic Long chain alternative to quaternary ammonium lipophilic long carbon chain will lead to the loss of anticancer activity of emodin quaternary ammonium.α-Naphthoquinone phenylmethane quaternary ammonium salt showed moderate anti-cancer activity, indicating that with electron transfer ability The introduction of lipophilic long carbon chain quaternary ammonium salt molecule can increase its anti-cancer activity.