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本文旨在确定热损伤对骨髓巨噬细胞在体外产生TNF、IL-1、PGE_2、C_3和这些细胞的细胞毒性方面的影响。选用6只雌性豚鼠,重400～500克,Ⅲ°烧伤面积50％作为实验组,6只未烧伤豚鼠为对照组。24小时后杀死动物取得骨髓巨噬细胞进行各项观察。结果表明:1)实验组骨髓巨噬细胞体外培养4小时和24小时产生的TNF,显著大于对照组。4天时两组均未测得。2)实验组骨髓巨噬细胞,体外培养4小时和24小时,产生的IL-1量和对照组无显著差别。4天时,实验组
This article aims to determine the effects of thermal injury on the production of TNF, IL-1, PGE 2, C 3 and the cytotoxicity of these cells in vitro by bone marrow macrophages. Six female guinea pigs weighing 400-500 g and 50% Ⅲ ° burn area were selected as experimental group and six non-burn guinea pigs as control group. Animals were sacrificed 24 hours later to obtain bone marrow macrophages for various observations. The results showed that: 1) TNF produced by macrophages cultured in vitro in experimental group at 4 hours and 24 hours was significantly larger than that in control group. Four days were not measured in both groups. 2) The experimental group of bone marrow macrophages, cultured in vitro 4 hours and 24 hours, the amount of IL-1 produced and the control group no significant difference. 4 days, experimental group