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目的观察脑梗死患者颈动脉粥样硬化斑块与血浆白细胞介素-18(IL-18)、超敏C反应蛋白(CRP)及脂联素水平的关系。方法对40例脑梗死患者行颈动脉超声检查,以发现颈动脉粥样硬化斑块并确定性质。检测脑梗死患者和30名健康体检者的血浆IL-18、CRP和脂联素的水平。结果 24例(60%)脑梗死患者有颈动脉斑块,16例(40%)无斑块;其中不稳定斑块17例(71%),稳定斑块7例(29%)。脑梗死患者的血浆脂联素水平均显著低于健康对照组(P均<0.05);不稳定斑块组的IL-18、CRP水平显著高于稳定斑块组及健康对照组。脂联素与IL-18、CRP水平呈负相关(P均<0.05)。结论血浆IL-18、CRP与颈动脉硬化易损斑块并发的脑梗死有关;血浆低脂联素水平可促进颈动脉粥样硬化的发生。
Objective To investigate the relationship between carotid atherosclerosis plaque and the levels of plasma interleukin-18 (IL-18), high-sensitivity C-reactive protein (CRP) and adiponectin in patients with cerebral infarction. Methods 40 patients with cerebral infarction underwent carotid ultrasonography to detect carotid atherosclerotic plaques and determine the nature. Plasma IL-18, CRP and adiponectin levels were measured in patients with cerebral infarction and in 30 healthy subjects. Results Twenty-four patients (60%) had carotid plaque and 16 (40%) had no plaque. Among them, 17 (71%) had unstable plaque and 7 (29%) had stable plaque. The levels of plasma adiponectin in patients with cerebral infarction were significantly lower than those in healthy controls (all P <0.05). The levels of IL-18 and CRP in unstable plaque group were significantly higher than those in stable plaque group and healthy control group. Adiponectin was negatively correlated with IL-18 and CRP levels (all P <0.05). Conclusions Plasma IL-18 and CRP are associated with cerebral infarction complicated with carotid atherosclerotic plaques. Low plasma adiponectin level may promote the development of carotid atherosclerosis.