脑源性神经营养因子在海马突触的传递和可塑性过程中起重要作用 ,与学习和记忆过程密切相关。它可调节海马神经元突触的基础传递 ,不但在海马早期长时程增强中起作用 ,还参与海马的晚期长时程增强。其作用方式包括突触前调控和突触后调控 ,调节途径包括钙离子及其通道、N 乙酰 D 门冬氨酸受体、丝分裂素相关蛋白激酶和3 磷酸肌醇激酶途径等。 Brain-derived neurotrophic factor plays an important role in synaptic transmission and plasticity in the hippocampus, and is closely related to learning and memory processes. It can regulate the basal transmission of synapses in the hippocampal neurons, not only play a role in the early long-term potentiation of the hippocampus, but also participate in the late long-term potentiation of the hippocampus. The mode of action includes presynaptic regulation and post-synaptic regulation. The regulatory pathways include calcium ion and its channel, N acetyl D aspartate receptor, mitogen related protein kinase and 3 phosphoinositide kinase pathway.