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目的 评价早期乳腺癌保留乳房和切除乳房两种治疗方法的疗效。方法 14 8例早期乳腺癌患者分保留乳房组 (保乳组 ,n =46 )和切除乳房组 (切乳组 ,n =10 2 )。前者行乳房的局部切除加腋淋巴结清扫 ,后者行乳房改良根治术。结果 139例患者获得随访 ,随访期 3～ 13年。两组 3年、5年、10年的生存率分别为 10 0 %、87.88%、73.6 8%和 10 0 %、85 .92 %、75 .0 0 % ,局部复发率分别为 6 .98%、9.0 9%、5 .2 6 %和 7.2 9%、8.45 %、7.5 0 % ,远处转移率分别为 2 .33%、12 .12 %、10 .5 3%和 3.13%、12 .6 8%、12 .5 0 %。两组各指标差异无显著 (P >0 .0 5 ) ;而保留乳房组手术创伤小 ,乳房美观满意率 81.4% ,与后者相比差异有显著性 (P <0 .0 1)。结论 与乳房的改良根治术相比 ,乳房的局部切除腋淋巴结清扫加根治性放疗对于早期乳腺癌疗效可靠 ,生活质量提高 ,是一种安全、有效的方法 ,但应有严格适应证。
Objective To evaluate the efficacy of two methods of breast cancer preservation and breast resection in early breast cancer. Methods Fourteen patients with early-stage breast cancer were divided into breast preservation group (bath-protection group, n=46) and breast-excision group (cut-off group, n=102). The former performed local resection of the breast plus axillary lymph node dissection, and the latter underwent modified radical mastectomy. Results 139 patients were followed up for a period of 3 to 13 years. The survival rates of the two groups at 3, 5, and 10 years were 100%, 87.88%, 73.68%, and 100%, 85.92%, and 75.00%, respectively, and the local recurrence rates were 6.98%. , 9%, 5.2% and 7.2%, 8.45 %, 7.50 %, distant metastasis rates were 2.33%, 12.12%, 10.5 3% and 3.13%, respectively, 12.6 8%, 12.50%. There was no significant difference between the two groups (P > 0.05), while the breast surgery group had a small surgical trauma and a beautiful breast satisfaction rate of 81.4%, which was significantly different from the latter (P < 0.01). Conclusions Compared with the modified radical mastectomy, local resection of the axillary lymph nodes and radical radiotherapy for breast cancer are effective and safe for early stage breast cancer. It is a safe and effective method, but there should be strict indications.