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用LACA纯种小白鼠对UDMH(偏二甲基肼)与MAPO三(2-甲基-1-氮丙啶)进行了显性致死试验。UDMH给药剂量为3.125—25毫克/公斤,腹腔注射(共三次)。MAPO为6.25—100毫克/公斤单次腹腔注射。结果表明前者为阴性,后者具有肯定的致突变作用及抗生育作用。突变指数最大达57.1。结合文献资料对结果进行了讨论。
A dominant lethal test of UDMH (dimethylhydrazine) and MAPO tris (2-methyl-1-aziridine) was performed with LACA purebred mice. UDMH was administered at a dose of 3.125-25 mg / kg intraperitoneally (three times in total). MAPO 6.25-100 mg / kg a single intraperitoneal injection. The results showed that the former is negative, the latter has a positive role in mutagenesis and anti-fertility. Mutation index up to 57.1. The results are discussed with reference to the literature.