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常规体外受精(IVF)胚胎移植(ET)和单精子卵泡浆注射术(ICSI)妊娠出生儿童的生长发育状况越来越受到关注。我们于2003年12月至2005年12月,通过研究体外受精后出生的2岁幼儿的智力发育情况,评价体外受精的安全性。对象与方法1.对象:2000年1月至2002年12月,我院生殖中心对不孕夫妇进行的857个 IVF-ET 周期,634个 ICSI 周期治疗。对其出生2岁左右(24.1±2.0个月)的幼儿各50例进行精神运动发育测定,分为 IVF 组和 ICSI 组各50例,对照组为本院同期自然分娩2岁幼儿50例。2.方法:精神运动发育评价:幼儿精神运动发育测定均取得其父母的知情同意,采用中南大学主持修订的“Bayley
Growth and development status of children born in pregnancy with conventional in vitro fertilization (IVF) embryo transfer (ETF) and sperm injection of follicular injection (ICSI) is receiving increasing attention. We evaluated the safety of in vitro fertilization by studying the intellectual development of 2-year-old infants born after in vitro fertilization from December 2003 to December 2005. Subjects and methods 1. Subjects: From January 2000 to December 2002, 857 IVF-ET cycles and 634 ICSI cycles were performed in infertile couples in our hospital’s reproductive center. The 50-year-old children aged 2 years old (24.1 ± 2.0 months) were divided into two groups: 50 cases in IVF group and 50 cases in ICSI group, and 50 cases in control group. 2. Methods: Evaluation of mental motor development: mental development in children measured their parents have obtained the informed consent of the University of Central South under the auspices of the revised ”Bayley