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目的 :研究多塞平凝胶新适应证。方法 :用 4 氨基吡啶 ( 4-AP)诱发小鼠舔体反应 ;组胺致家兔皮肤血管通透性增高 ;二甲苯及蛋清分别制成小鼠耳片肿胀和足跖肿胀模型 ,2 4 -二硝基氯苯致小鼠变应性接触性皮炎动物模型。结果 :多塞平凝胶组与凝胶基质对照组相比能明显抑制舔体反应数 ,分别为 1 0± 0 4 2 9和 2 6 7±4 83,有显著性差异 (P <0 0 1 )。多塞平凝胶也能对抗组胺引起的皮肤血管通透性增高。对小鼠二甲苯致耳部水肿、小鼠蛋清引起的足跖肿胀的炎性模型亦呈现明显的抗炎作用 ,也能抑制 2 4 -二硝基氯苯诱发的炎症反应。结论 :多塞平的新适应证是治瘙痒
Objective: To study the new indication of doxepin gel. Methods: 4-aminopyridine (4-AP) was used to induce mouse lick reaction. Histamine induced hypervascular permeability of rabbit skin. Xylene and egg white were used to make ear swelling and paw edema models in mice. Animal models of allergic contact dermatitis caused by dinitrochlorobenzene in mice. Results: Compared with the gel matrix control group, doxepin gel group could significantly inhibit the number of lick reaction, which were 10 ± 0 429 and 26 7 ± 4 83, respectively, with significant difference (P <0 0 1 ). Doxepin gel also counteracts the increased vascular permeability caused by histamine. It also showed obvious anti-inflammatory effect on the mouse model of ear edema caused by xylene and inflammatory model of plantar swelling caused by mouse egg white, and also inhibited the inflammatory reaction induced by 2,4-dinitrochlorobenzene. Conclusion: The new indication for doxepin is pruritus