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目的:观察ORS联合葡萄糖酸锌治疗小儿腹泻的临床疗效以及安全性。方法:选取我院2012年3月到2013年9月收治的90例腹泻患儿作为研究对象,采用随机的方式经将所有的患儿均分成两组,分别作为治疗组和对照组,对两组患儿均采用补充电解质、使用肠粘膜保护剂与微生物制剂、纠正酸中毒、补液和抗感染等方法进行对症的基础治疗。在此基础上对于对照组的患儿采用口服或者胃滴注的形式使用ORS口服液进行治疗,对于治疗组的患儿使用ORS联合葡糖酸锌片进行治疗。对两组患儿均治疗2周,观察两组患儿的临床治疗效果。结果:经过两周的治疗之后,两组患儿的病情都发生明显的好转,其中对照组患儿显效的有21例,有效的为12例,无效的为12例,治疗总有效率为73.33%,治疗组患儿显效的有31例,有效的有13例,无效的有1例,治疗的总有效率为97.78%,两组患儿治疗的总有效率之间的差异具有统计学意义(P<0.05)。结论:RS联合葡萄糖酸锌治疗小儿轮状病毒肠炎无明显不良反应,方法简便,价格便宜。合理补锌对腹泻有明显疗效,可改善轮状病毒肠炎的临床表现,腹泻情况,值得临床推广使用。
Objective: To observe the clinical efficacy and safety of ORS combined with zinc gluconate in the treatment of children with diarrhea. Methods: Ninety children with diarrhea who were treated in our hospital from March 2012 to September 2013 were selected as study subjects. All children were randomly divided into two groups as treatment group and control group. Group children were supplemented with electrolyte, the use of intestinal mucosal protective agent and microbial agents, to correct acidosis, rehydration and anti-infective methods for symptomatic treatment. On this basis, ORS oral solution was administered orally or by gastric instillation to children in the control group, and ORS combined with zinc gluconate tablets was administered to children in the treatment group. The two groups of children were treated for 2 weeks, the clinical efficacy of two groups were observed. Results: After two weeks of treatment, the two groups of children had a significant improvement in the condition, in which the control group of children markedly effective in 21 cases, effective in 12 cases, ineffective in 12 cases, the total effective rate was 73.33 %, The treatment group of children markedly effective in 31 cases, effective in 13 cases, ineffective in 1 case, the total effective rate was 97.78%, the total effective rate of treatment of children between the two groups was statistically significant (P <0.05). Conclusion: RS combined with zinc gluconate treatment of children rotavirus enteritis no obvious adverse reactions, the method is simple and cheap. Rational zinc supplementation has a significant effect on diarrhea, can improve the clinical manifestations of rotavirus enteritis, diarrhea, worthy of clinical promotion and use.