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在泰缅边界,恶性疟几乎对所有常用抗疟药都产生了抗性,该地区已停止使用氯喹和周效磺胺-乙胺嘧啶。作者对540例血检确诊的当地克伦族成人和儿童恶性疟病例进行研究,比较口服青蒿琥酯或蒿甲醚与甲氟喹联用治疗多重抗药性恶性疟的效果。将病例随机分入3个治疗方案组:1)甲氟喹组(M25组,182例),25mg(基质)/kg单剂。2)青蒿琥酯与甲氟喹组(MAS组,180例)口服青蒿琥酯4mg/kg·d,每天一次,连服3天,第2天加服单剂甲氟喹25mg/kg。3)蒿甲醚与甲氟喹组(MAM组,178例)口服蒿甲醚4mg/kg·d每天一次,连服3天,第2天加服单剂甲氟喹25mg/kg。服药后每天制厚血膜并血检直至原虫血症消失,以后每周追踪血检1次,
On the Thai-Myanmar border, falciparum malaria is resistant to almost all commonly used antimalarial drugs, and chloroquine and psoxacin have been discontinued in the area. The authors studied 540 Crohn’s adult and pediatric cases of falciparum malaria diagnosed by blood tests and compared the efficacy of oral administration of artesunate or artemether in combination with mefloquine in the treatment of multi-drug resistant falciparum malaria. The patients were randomized into three treatment groups: 1) mefloquine group (M25 group, 182 cases), 25 mg (matrix) / kg single dose. 2) Artesunate and mefloquine group (MAS group, 180 cases) were given artesunate 4mg / kg · d orally once daily for 3 days. On the second day, a single dose of mefloquine 25 mg / kg . 3) Artemether and mefloquine (MAM group, 178 cases) were given artemether 4mg / kg · d once daily for 3 days. On the second day, a single dose of mefloquine 25mg / kg was added. After taking the medication every day thick blood film and blood tests until the parasitemia disappeared, after a week follow-up blood tests 1,