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目的观察地奥司明对深Ⅱ度烧伤患者早期水肿的临床疗效。方法选择深Ⅱ度烧伤后的早期水肿患者60例,创面主要位于四肢,面积10-30%,随机分为两组,对照组给予常规治疗,治疗组在常规治疗基础上给予地奥司明口服治疗。评估患者治疗前后的肢体肿胀及疼痛程度,并观察药物不良反应、患者创面的愈合时间及创面瘢痕增生情况。结果两组患者治疗前创伤肢体周径、疼痛评分比较无统计学差异(P>0.05),治疗后创伤肢体肿胀、疼痛程度较治疗前均有所降低,且与对照组相比,治疗组肢体周径、疼痛评分下降更为显著,差异均有统计学意义(P<0.05)。两组患者的创面愈合时间比较,治疗组较对照组显著缩短,差异有统计学意义(P<0.05)。治疗组瘢痕指数较对照组明显降低,愈合情况好转(P<0.05)。结论地奥司明能够减轻烧伤创面水肿的发生及水肿对组织的破坏,维护内环境稳定,加速创面的修复再生,减少瘢痕形成。
Objective To observe the clinical effect of des oslimin on early edema in deep second degree burn patients. Methods Sixty patients with early edema after deep partial thickness burn were selected. The wounds were mainly located on the extremities with an area of 10-30%. They were randomly divided into two groups. The control group was given routine treatment. The treatment group was given oral administration of Diazepam on the basis of routine treatment treatment. The degree of limb swelling and pain before and after treatment was evaluated. Adverse drug reactions, wound healing time and wound scar hyperplasia were observed. Results Before treatment, there was no significant difference in the scores of the wounds’ limbs between the two groups (P> 0.05). After treatment, the swelling and pain of trauma limbs were lower than those before treatment. Compared with the control group, The diameter and pain score decreased more significantly, the differences were statistically significant (P <0.05). The wound healing time of the two groups was significantly shorter than that of the control group, the difference was statistically significant (P <0.05). The index of scar in treatment group was significantly lower than that in control group, healing condition improved (P <0.05). Conclusion Diosmin can reduce the incidence of wound edema and edema on tissue damage, maintain the stability of the internal environment, accelerate wound repair and regeneration, reduce scar formation.