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目的探讨以免疫法粪便隐血试验与血癌胚抗原(CEA)检测为主要方法提高早期大肠癌的诊断率。方法应用问卷调查,按易感因素将研究对象分组,进行免疫法粪便隐血试验(iFOBT)、CEA、肠镜及病理检查。结果依据问卷调查将6997例研究对象分为大肠癌低度危险组(n=4551)、可疑组(n=2085)、高度危险组(n=361)。3组iFOBT阳性率依次升高,差异具有统计学意义(P<0.05,P<0.01)。共检出早期大肠癌6例,其中高度危险组5例,可疑组1例。根据结肠镜检查结果分为结肠癌、结肠息肉、结肠炎、正常组,结肠癌组iFOBT、CEA结果明显高于其他组,差异有统计学意义(P<0.05)。结论 iFOBT可以作为早期大肠癌筛查的主要方法,iFOBT和CEA联合检测可以提高早期结肠癌的检出率。
Objective To investigate the diagnostic methods of improving the early colorectal cancer by the immunohistochemical fecal occult blood test and the detection of the blood carcinoembryonic antigen (CEA) as the main method. Methods A questionnaire survey was conducted. According to the susceptibility factors, the subjects were divided into groups and subjected to immuno-faecal occult blood test (iFOBT), CEA, colonoscopy and pathological examination. Results According to the questionnaire, 6997 subjects were divided into low risk group of colorectal cancer (n = 4551), suspicious group (n = 2085) and high risk group (n = 361). The positive rate of iFOBT in three groups increased in turn, the difference was statistically significant (P <0.05, P <0.01). A total of 6 cases of early-stage colorectal cancer were detected, including 5 cases of high-risk group and 1 case of suspicious group. The results of colonoscopy, colon polyps, colitis, normal group, colon cancer group iFOBT, CEA results were significantly higher than the other groups, the difference was statistically significant (P <0.05). Conclusion iFOBT can be used as a primary screening method for early colorectal cancer. Combined detection of iFOBT and CEA can improve the detection rate of early colon cancer.