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乙型肝炎病毒（ HBV）的高感染率，是隐匿性 HBV感染（ OBI）存在的基础。 OBI是一种特殊形式的HBV感染，可通过输血、器官移植、血液透析等方式传播，其与慢性肝病、肝细胞癌及慢性丙型肝炎的发生、发展相关。 OBI存在多种发生机制，随着研究技术的不断发展，OBI的检测方法也较为多样。建立操作简单、敏感、特异的HBV核酸检测方法，可以为实现OBI的快速筛查提供依据，以减少与它相关的潜在威胁。“,”The high infection rate of hepatitis B virus(HBV) is the basis of the existence of occult hepa-titis B virus infection(OBI).OBI is a special form of HBV infection which can be spread through blood transfusion,organ transplantation, dialysis, etc.It is associated with the occurrence and development of chronic liver disease,chronic hepatitis C and hepatocellular carcinoma.Due to the varied pathogenesis mech-anisms of OBI, with the development of research? techniques,there are different kinds of detection methods for OBI.The establishment of simple,sensitive and specific HBV nucleic acid detection method can provide a basis for the rapid screening of OBI,to reduce the potential threats.