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１６种抗菌药物对从小儿腹泻粪便标本中分离到的不同血清型别的１１株肠致病性大肠杆菌（ＥＰＥＣ），９株肠侵袭性大肠杆菌（ＥＩＥＣ）及１５０株志贺氏菌进行最低抑菌浓度（ＭＩＣ）测定。结果显示，各菌株对头孢三嗪、丁胺卡那、头孢哌酮和头孢唑啉均较敏感（ＭＩＣ９０为＜２～３２ｍｇ／Ｌ）；氟哌酸、庆大霉素和氟霉素对两者的ＭＩＣ９０相差较大（对致病性大肠杆菌的ＭＩＣ９０分别是＞２５６、６４和＞１２８ｍｇ／Ｌ，对志贺氏菌的ＭＩＣ９０分别是６４、１０和３０ｍｇ／Ｌ）．而其余９种抗菌药物的抑菌效果都很差（除卡那霉素外，ＭＩＣ９０均大于１００ｍｇ／Ｌ）。
Sixteen antimicrobial agents were administered to 11 strains of enteropathogenic E.coli (EPEC), 9 strains of enteroaggregative Escherichia coli (EIEC) and 150 strains of Shigella isolated from stool specimens of infantile diarrhea for different serotypes Bacteriostatic concentration (MIC) determination. The results showed that each strain was more sensitive to cefotaxime, amikacin, cefoperazone and cefazolin (MIC90 <2 ~ 32mg / L); norfloxacin, gentamicin and chlorothalonil (MIC90 for pathogenic E. coli were> 256, 64 and> 128 mg / L, respectively, and MIC90 for Shigella were 64, 10 and 30 mg / L, respectively). The antibacterial effect of the remaining nine kinds of antibiotics are very poor (except kanamycin, MIC90 were greater than 100mg / L).