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目的探讨氟伐他汀对急性心肌梗死患者左心室重构的影响。方法将急性心肌梗死患者随机分成治疗组和对照组,对照组行基础治疗(阿司匹林、氯吡格雷、β-受体阻滞剂),治疗组在此基础上加用氟伐他汀缓释片,坚持服用24周后分析心率、血压、超声心动图等相关指数的变化。结果治疗组的显效率和总有效率显著高于对照组(P<0.05);心率和血压较对照组显著降低(P<0.05);治疗组左室收缩末期容积(LVESV)和左室舒张末期容积(LVEDV)的下降幅度明显高于对照组;左室射血分数(LVEF)和左室快速充盈E波最大流速(VE)和心房充盈A波最大流速(VA)比值(VE/VA)也明显高于对照组;左室心肌重量指数(LVMI)增高幅度显著小于对照组(均P<0.05)。结论氟伐他汀能显著抑制急性心肌梗死患者左心室重构。
Objective To investigate the effect of fluvastatin on left ventricular remodeling in patients with acute myocardial infarction. Methods Acute myocardial infarction patients were randomly divided into treatment group and control group. The control group received basic therapy (aspirin, clopidogrel and β-blockers). On the basis of this, fluvastatin sustained- Adhere to taking 24 weeks after the analysis of heart rate, blood pressure, echocardiography and other related index changes. Results The effective rate and total effective rate of the treatment group were significantly higher than those of the control group (P <0.05); heart rate and blood pressure were significantly lower than those of the control group (P <0.05); LVESV and left ventricular end-diastolic volume (LVEDV) was significantly lower than that of the control group. The left ventricular ejection fraction (LVEF) and left ventricular filling velocity (VE) and the ratio of atrial filling A wave maximum velocity (VE / VA) Significantly higher than the control group; LVMI increased significantly less than the control group (all P <0.05). Conclusion Fluvastatin can significantly inhibit left ventricular remodeling in patients with acute myocardial infarction.