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目的采用Meta分析比较NP和GP方案治疗晚期非小细胞肺癌在有效率和骨髓抑制方面的优缺点。方法检索有关NP和GP方案治疗晚期非小细胞肺癌的临床对比研究,分别对入选的研究进行文献评价,进行Meta分析。结果从1994年~2005年共有12个研究入选,实验组413例。对照组共401例。分析结果显示：有效率RR值为1.05,95%可信区间为0.90~1.23,总体效应检验Z=0.63,P>0.05,无统计学意义；白细胞下降RR值为1.43,95%可信区间为1.26~1.61,总体效应检验Z=5.58,P<0.05,有统计学意义；血小板下降RR值为0.83,95%可信区间为0.72~0.96,总体效应检验Z=2.44,P0. 05, no statistical y significant;leukopenia RR value of 1.43, 95%CI 1.26-1.61, test for overal ef ect Z=5. 58, P<0. 05, there was significant;thrombocytopenia RR was 0.83, 95%CI 0.72~0.96, test for overal ef ect Z=2. 44, P<0. 05, was statistical y significant. Conclusion:NP and GP schemes are ef ective in therapy ofnon- smal cel lung cancer.Decrease of leukocyte and platelet are two adverse ef ects. Decrease of leukocyte is greater in NP schemes, decrease of platelet is greater in GP schemes.