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目的探讨尿酸水平和高血压病与帕金森病(PD)的关系。方法采用病例对照研究,收集门诊或住院的PD患者372例(PD组),另选择性别、年龄与PD组匹配的对照者372名(对照组)为研究对象。采用Mantel-Haenszel(M-H)χ~2检验等统计学方法分析两组的一般情况、尿酸水平、高血压病病史、高血压病病程(分为<10年和≥10年)和高血压病级别(按收缩压:Ⅰ级=140~159 mm Hg、Ⅱ级=160~179 mm Hg、Ⅲ级≥180 mm Hg)与PD症状(UPDRSⅡ/Ⅲ)和严重程度(H-Y分级)的关系。结果 PD组中,与非高尿酸血症者比较,高尿酸血症患者患PD的危险性降低(OR=0.24,95%CI:0.15~0.37);与非高血压病患者比较,高血压病患者患PD的危险性降低(OR=0.50,95%CI:0.37~0.70)。对高血压病患者分别按高血压病级别(Ⅰ~Ⅲ级)以及高血压病病程<10年和≥10年分层后进行单因素分析,依然存在负相关(P<0.05)。此外,PD组随H-Y分级增加,高血压病患病率和尿酸水平均呈下降趋势;且PD合并高血压病患者的UPDRSⅡ/Ⅲ评分明显低于PD非合并高血压病患者,均差异有统计学意义(P<0.01)。结论高尿酸血症和高血压病与PD存在负相关性。
Objective To investigate the relationship between uric acid level and hypertension and Parkinson’s disease (PD). Methods A case-control study was conducted in 372 PD patients (PD group) outpatient or inpatient, and 372 matched controls (control group) of gender and age were selected as the study subjects. Mantel-Haenszel (MH) χ ~ 2 test and other statistical methods to analyze the general situation of the two groups, uric acid levels, history of hypertension, duration of hypertension (divided into <10 years and ≥ 10 years) and hypertension (Systolic pressure: grade I = 140-159 mm Hg, grade II = 160-179 mm Hg, grade III ≥ 180 mm Hg) and the relationship between PD symptoms (UPDRS II / III) and severity (HY grade). Results In PD group, the risk of PD in patients with hyperuricemia was lower than that in non-hyperuricemia patients (OR = 0.24, 95% CI: 0.15-0.37). Compared with non-hypertensive patients, Patients had a reduced risk of developing PD (OR = 0.50, 95% CI: 0.37 to 0.70). There was still a negative correlation (P <0.05) in the univariate analysis of patients with hypertension according to the level of hypertension (Grade Ⅰ ~ Ⅲ) and the duration of hypertension (<10 years and ≥10 years). In addition, the PD group increased with the HY classification, the prevalence of hypertension and uric acid levels showed a downward trend; and PD combined with hypertension in patients with UPDRS Ⅱ / Ⅲ scores were significantly lower than in patients with non-combined hypertension, were statistically significant differences Significance (P <0.01). Conclusion Hyperuricemia and hypertension are negatively correlated with PD.