Stabilization of the constrained switched nonlinear systems is an attractive research subject. Predictive control can handle variable constraints well and make the system stable. Its stability is typically based on an assumption of initial feasibility of the optimization problem; however the set of initial conditions, starting from where a given predictive formulation is guaranteed to be feasible, is not explicitly characterized. In this paper, a hybrid predictive control method is proposed for a class of switched nonlinear systems with input constraints and un-measurable states. The main idea is to design a mixed controller using Lyapunov functions and a state observer, which switches appropriately between a bounded feedback controller and a predictive controller, and to give an explicitly characterized set of initial conditions to stabilize each closed-loop subsystem. For the whole switched nonlinear system, a suitable switched law based on the state estimation is designed to orchestrate the transitions between the consistituent modes and their respective controllers, and to ensure the whole closed-loop system’s stability. The simulation results for a chemical process show the validity of the controller proposed in this paper. Stabilization of the constrained switched nonlinear systems is an attractive research subject. Predictive control can handle variable constraints well and make the system stable. Its stability is typically based on an assumption of initial feasibility of the optimization problem; starting the set of initial conditions, starting from this a given predictive formulation is guaranteed to be feasible, is not resolved characterized. In this paper, a hybrid predictive control method is proposed for a class of switched nonlinear systems with input constraints and un-measurable states. The main idea is to design a mixed controller using Lyapunov functions and a state observer, which switches suitably between a bounded feedback controller and a predictive controller, and to give an explicitly characterized set of initial conditions to stabilize each closed-loop subsystem. suitable switched law based on the state estimation is designed to orchest rate the transitions between the consistituent modes and their respective controllers, and to ensure the whole closed-loop system’s stability. The simulation results for a chemical process show the validity of the controller proposed in this paper.