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目的 检测超排卵治疗的不孕症患者血清血管内皮生长因子 (VEGF)和雌二醇 (E2 )水平 ,探讨VEGF和E2 对卵巢过度刺激综合征 (OHSS)的预测作用。方法 采集 4 1例高危患者注射HCG前和注射后 34～ 36h血清标本 ,测定VEGF和E2 水平 ,并与同期 30例非高危病人进行对照。结果 高危各组在注射HCG前 ,血清VEGF水平与对照组无显著性差别 (P >0 0 5 ) ,注射后OHSS组VEGF水平明显升高 (P <0 0 1) ,显著高于对照组和非OHSS组 (P <0 0 1) ;高危各组E2 水平在注射HCG日显著高于对照组 ,注射后OHSS组E2 水平与注射前比明显升高 (P <0 0 1) ,显著高于对照组 (P <0 0 1) ,但非OHSS组变化不明显 (P >0 0 5 )。结论 VEGF在HCG注射后可作为预测OHSS的标志物 ,结合连续测定E2 水平 ,有助于预测和治疗卵巢过度刺激综合征。
Objective To detect the levels of serum vascular endothelial growth factor (VEGF) and estradiol (E2) in patients with infertility treated with superovulation and to investigate the predictive value of VEGF and E2 on ovarian hyperstimulation syndrome (OHSS). Methods Serum samples were collected before injection of HCG and 34-36 h after injection in 41 high-risk patients. VEGF and E2 levels were measured and compared with 30 non-high-risk patients in the same period. Results Before high-risk HCG injection, there was no significant difference in serum VEGF levels between the two groups (P> 0.05), and the levels of VEGF in OHSS group were significantly higher (P <0.01) than those in control group and The levels of E2 in high-risk groups were significantly higher than those in control group on the day of HCG injection, and the levels of E2 in OHSS group were significantly higher than those before injection (P <0.01), which were significantly higher than those in non-OHSS group (P <0.01) Control group (P <0.01), but the changes of non-OHSS group were not obvious (P> 0.05). Conclusion VEGF can be used as a marker for predicting OHSS after HCG injection. Combined with continuous determination of E2 level, VEGF is helpful to predict and treat ovarian hyperstimulation syndrome.