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目的:探讨康莱特注射液与吉西他滨和顺铂(GP方案)治疗晚期非小细胞肺癌(NSCLC)患者的临床疗效及其对免疫功能的影响。方法:选取2013年9月—2016年7月间收治的NSCLC患者82例,采用随机分组法将其分为对照组40例和观察组42例;对照组患者给予吉西他滨和顺铂(GP方案)治疗,观察组患者在对照组基础上加用康莱特注射液治疗,比较两组患者用药后的免疫功能各指标的变化情况、生存质量的改善情况,以及治疗后的总有效率和化疗期间不良反应的发生率。结果:治疗后,观察组患者CD4、CD3、CD4/CD8测得值以及按生活质量评价量表(SF-36)(躯体功能、情绪功能、心理功能、社会功能等)评分值均低于对照组(P<0.05);观察组患者用药后的脱发、末梢神经炎、骨髓抑制等不良反应的发生率低于对照组(P<0.05);观察组患者治疗后的总缓解率为40.48%稍高于对照组为37.50%(P>0.05)。结论:采用康莱特注射液与GP方案治疗NSCLC患者可有效改善其免疫功能各指标和生活质量。
Objective: To investigate the clinical effect of Kanglaite Injection and gemcitabine and cisplatin (GP regimen) in the treatment of patients with advanced non-small cell lung cancer (NSCLC) and its effect on immune function. Methods: Eighty-two NSCLC patients were enrolled from September 2013 to July 2016. They were randomly divided into control group (n = 40) and observation group (n = 42). Patients in the control group were treated with gemcitabine and cisplatin (GP) The patients in the treatment group and the observation group were treated with Kanglaite injection on the basis of the control group. The changes of immune function indexes, the quality of life improvement, the total effective rate after treatment and the adverse reactions during chemotherapy were compared between the two groups The incidence of reaction. Results: After treatment, the scores of CD4, CD3, CD4 / CD8 in the observation group and SF-36 (body function, emotional function, psychological function, social function, etc.) (P0.05) .The incidence of adverse reactions such as alopecia, peripheral neuritis and myelosuppression in the observation group was lower than that in the control group (P0.05). The total remission rate of the observation group after treatment was slightly higher than that of the control group (40.48%) In the control group was 37.50% (P> 0.05). Conclusion: The use of Kanglaite Injection and GP regimen in patients with NSCLC can effectively improve the immune function of various indicators and quality of life.