论文部分内容阅读
用放射免疫法测定３１例急性脑梗塞患者和１６例高血压患者血浆及体外诱生的单核细胞源性及地塞米松（ＤＸＭ）干预后的内皮素（ＥＴ）水平。结果发现：急性脑梗塞组体外诱生的单核细胞源性ＥＴ水平明显增高，并与血浆中ＥＴ水平及神经损伤程度正相关；ＤＸＭ干预后，体外诱生的单核细胞源性ＥＴ水平降低。提示：急性脑梗塞时，单核细胞增加ＥＴ的合成与释放可能是其参与缺血性脑损伤过程的机制之一，而ＤＸＭ则抑制其合成与释放，具有改善缺血性脑损伤的作用
The levels of endothelin (ET) in plasma and in vitro induced by monocyte-derived and dexamethasone (DXM) intervention in 31 patients with acute cerebral infarction and 16 patients with hypertension were measured by radioimmunoassay. The results showed that the level of monocyte-derived ET induced by acute cerebral infarction was significantly increased in vitro and positively correlated with the level of plasma ET and the degree of neural damage. The level of monocyte-derived ET induced by DXM was decreased in vitro . It is suggested that the synthesis and release of ET by monocytes may be one of the mechanisms involved in the process of ischemic brain injury in acute cerebral infarction, whereas DXM inhibits the synthesis and release of ET and has the effect of improving ischemic brain injury