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目的探讨雄雌激素、细胞凋亡在前列腺增长和前列腺增生（ＢＰＨ）发病中的作用。方法应用ＤＮＡ末端原位标记的方法对正常前列腺移行带（１０例）和周围带（１０例）以及ＢＰＨ组织（２０例）标本进行了细胞凋亡率的研究，并应用放射免疫学技术检测了相应组织的双氢睾酮（ＤＨＴ）和雌二醇（Ｅ２）含量。结果正常前列腺移行带，周围带ＤＨＴ和Ｅ２的差异无显著性，ＢＰＨ组织中的Ｅ２含量（平均６．６３ｎｇ／ｇ蛋白）虽高于正常前列腺的移行带含量３．１５ｎｇ／ｇ蛋白，但差异无显著性（Ｐ＝０．１）。正常前列腺周围带细胞凋亡率（４１．２±３．９）％显著高于移行带（２９．７±４．０）％，Ｐ＜０．０５，后者又非常显著地高于ＢＰＨ组织（３９±１．１）％，Ｐ＜０．００１。正常与增生前列腺组织内的ＤＨＴ及Ｅ２含量与细胞凋亡率之间无明显相关性。正常前列腺组织中，前列腺增生的起始部位移行带的细胞凋亡率已明显下降，随着年龄的增长，凋亡率进一步下降，导致ＢＰＨ。细胞凋亡率与其组织的ＤＨＴ、Ｅ２无明显相关性。结论前列腺导管系统的远、近端（周围带、移行带）上皮细胞结构形态不同，其周围的间质亦有差异，因此即使在接受相同量的雄、雌激素情况下，这些细胞的反应并不相同。
Objective To investigate the role of estrogen and apoptosis in the pathogenesis of benign prostatic hyperplasia (BPH) and benign prostatic hyperplasia (BPH). Methods The apoptosis rate of normal prostate transitional zone (10 cases), peripheral band (10 cases) and BPH tissue (20 cases) was studied by DNA end-in-situ labeling method. The rate of apoptosis was detected by radioimmunoassay Corresponding tissue dihydrotestosterone (DHT) and estradiol (E2) content. Results There was no significant difference between normal and benign prostatic hyperplasia in the band, but there was no difference between DHT and E2 in the surrounding area. The content of E2 in BPH tissue (mean 6.63 ng / g protein) was higher than that in normal prostate (3.15 ng / g protein) No significant (P = 0.1). The apoptotic rate of normal prostate around the normal (41.2 ± 3.9)% was significantly higher than that of the transition zone (29.7 ± 4.0)%, P <0.05, which was significantly higher than that of BPH (39 ± 1.1)%, P <0.001. Normal and hyperplasia of prostate tissue DHT and E2 content and apoptosis rate between no significant correlation. In normal prostatic tissue, the rate of apoptotic cells in the transition zone of the prostatic hyperplasia has obviously decreased. With the increase of age, the apoptosis rate further decreases, leading to BPH. There was no significant correlation between apoptosis rate and DHT and E2 in their tissues. Conclusion The structures of the epithelial cells in the distal and proximal (peripheral band, transitional zone) of the prostatic ductal system are different and their interstitial spaces are also different. Therefore, even in the case of receiving the same amount of male and female estrogen, the response of these cells Are not the same.