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项目摘要问题现状:恶性肿瘤病人都伴有不同程度的营养不良。营养不良直接影响化学治疗药物的用量及其疗效。目的:通过肠内营养支持,提高耐药肿瘤病人的化疗药物的用量及其疗效。方法:以耐药的胃癌、大肠癌、肺癌患者为研究对象。随机分为肠内营养组、肠外营养组、无营养支持组。技术路线:于化疗前1～3天、化疗后第3天、第7天、第14天、第21天抽血等检测,进行化疗药物用量、疗效、毒副作用、生活质量、抗氧化能力、肠屏障功能、感染、免疫功能、营养状况等
Project Summary The status of the problem: Malignant tumors are associated with varying degrees of malnutrition. Malnutrition directly affects the amount of chemotherapeutic drugs and their efficacy. OBJECTIVE: To increase the dosage of chemotherapeutic drugs and its efficacy in patients with drug-resistant tumors through enteral nutrition support. Methods: The drug-resistant gastric cancer, colorectal cancer, lung cancer patients as the research object. Randomly divided into enteral nutrition group, parenteral nutrition group, no nutritional support group. Technical route: 1 ~ 3 days before chemotherapy, 3 days after chemotherapy, 7 days, 14 days, 21 days of blood testing, the amount of chemotherapy drugs, efficacy, side effects, quality of life, antioxidant capacity, Intestinal barrier function, infection, immune function, nutritional status and so on