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本研究用随机、对照、单盲试验比较了吡喹酮和羟氨喹对曼氏血吸虫病的疗效。8～14岁、大便曼氏血吸虫卵阳性的当地某小学的男、女学生,分为3组:吡喹酮组、羟氨喹组和不治疗的对照组。吡喹酮(Biltricide,Bayer,AG)每片600mg,按40mg/kg计算,羟氨喹(Vsncil,Pfizer)每胶丸250mg,按15mg/kg计算,均单剂口服给药。分别在服药后24小时,和服药后1、2、6个月各随访一次。药物的副反应除腹部不适吡喹酮组(63%)显著高于羟氨喹组(16%)外,其余基本相同。副反应均轻微,历时短暂,不需特殊处理,而在血吸虫病的症状改善和减少虫卵
In this study, a randomized, controlled, single-blind trial of praziquantel and hydroxyammonia for the treatment of Schistosoma mansoni. 8 to 14 years old, male and female students from a local primary school who were infected with Schistosoma mansoni were divided into 3 groups: praziquantel group, hydroxyquine group and untreated control group. Pseudoquinone (Biltricide, Bayer, AG) 600mg per tablet, calculated according to 40mg / kg, hydroxyquinquale (Vsncil, Pfizer) 250mg per capsule, according to 15mg / kg, were a single dose of oral administration. Respectively 24 hours after taking medicine, and taking 1,2,6 months after taking each one. Side effects of drugs in addition to abdominal discomfort praziquantel group (63%) was significantly higher than the hydroxylamine group (16%), the rest are basically the same. Side effects are mild, lasted for a short time, without special treatment, while the symptoms of schistosomiasis to improve and reduce the eggs