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染色体、质粒作为鼠疫耶尔森菌(鼠疫菌)的遗传基础,决定着鼠疫菌的生物学特征及致病力。在现有的鼠疫菌全基因组序列中,各型菌株基因组都表现出G+C含量偏差、存在丰富的插入序列、大量的假基因及频繁的基因重组等特征,这些都是鼠疫菌迅速进化的关键。鼠疫菌遗传学通过基因组学、比较和进化基因组学的研究,确定鼠疫菌对人体的毒力因子和致病机制,探索鼠疫菌致病性和进化的遗传学机制,从而为鼠疫的流行监测及疫苗研制等防治工作提供科学的理论依据。
Chromosomes and plasmids as the genetic basis of Yersinia pestis (Yersinia pestis) determine the biological characteristics and virulence of Yersinia pestis. In the existing whole genome sequence of Y. pestis, the genotypes of various strains showed the G + C content deviation, abundant insertion sequences, a large number of pseudogenes and frequent gene recombination and so on, all of which are rapid evolution of Yersinia pestis The essential. Yersinia pestis Genetics Genomics, comparative and evolutionary genomics research to determine the virulence factors and pathogenic mechanism of Yersinia pestis to humans, to explore the pathogenesis of Y. pestis and the genetic mechanism of evolution, so as to monitor the epidemic of plague Vaccine research and other prevention and control work to provide a scientific theoretical basis.