新生儿胆红素脑病(NBE)是新生儿高胆红素血症最严重的并发症,发生率低,病死率高,幸存者多遗留严重神经系统后遗症[1]。其早期症状不明显,临床诊断难度大。随着医疗技术的进步,其发生率明显降低,但仍时有发生,因而寻找高敏感性、高特异性的检测指标以助早期诊断及干预尤为重要。1胆红素脑病流行病学特点近年来,国外相继开展了多项关于胆红素脑病的大规模流行病学调查:丹麦2000-2007年[2]、加拿大2002 Neonatal bilirubin encephalopathy (NBE) is the most serious complication of neonatal hyperbilirubinemia, with a low incidence and high mortality, leaving many survivors with severe neurological sequelae [1]. Its early symptoms are not obvious, clinical diagnosis is difficult. With the progress of medical technology, the incidence rate has obviously decreased, but it still occurs from time to time. Therefore, it is very important to find high sensitivity and high specificity of the detection index to help early diagnosis and intervention. A bilirubin encephalopathy epidemiological characteristics In recent years, a large number of foreign countries have conducted a large-scale epidemiological survey of bilirubin encephalopathy: Denmark, 2000-2007 [2], Canada 2002