目的 :探讨血浆中异常凝血酶原 (Abnormal prothrombin,APT)含量对肝癌的诊断意义 ,提高原发性肝癌早期诊断的敏感性。方法 :采用双抗体酶联免疫法在 331人中进行血浆 APT含量的测定 ,并与 AFP免疫测定相比较。结果 :1 66例肝癌患者中阳性率达到 90 .4% ,高于 AFP检测。结论 :血浆中 APT含量增高对肝癌有诊断意义 ,本研究所建立的 APT含量检测方法对肝癌诊断特异性强 ,灵敏度高 ,是理想的肝肿瘤标志物。 Objective: To investigate the significance of abnormal prothrombin (APT) content in plasma for the diagnosis of hepatocellular carcinoma and to improve the sensitivity of early diagnosis of primary hepatocellular carcinoma. METHODS: Plasma APT levels were measured in 331 persons using double-antibody enzyme-linked immunosorbent assay and compared with AFP immunoassay. Results: The positive rate of 1 out of 66 liver cancer patients reached 90.4%, which was higher than that of AFP test. Conclusion : The increase of plasma APT content is of diagnostic significance to liver cancer. The APT content detection method established in this study has a high specificity and high sensitivity for the diagnosis of liver cancer. It is an ideal liver tumor marker.