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本文用金黄色葡萄球菌及其稳定 Ｌ型， 经多种方式感染雌性昆明种小鼠， 发现雌鼠妊娠率、每胎分娩的子鼠数及子鼠体重均低于对照组， 差异有显著性 （ Ｐ＜ ００１ ， Ｐ＜ ００１ ， Ｐ＜ ００５） 。对感染鼠子宫内膜、胎盘及子鼠肝、肺等组织作免疫组化及金葡菌 Ｌ型地高辛核酸探针原位杂交， 结果发现金葡菌 Ｌ 型感染雌鼠子宫内膜、胎盘及子鼠肝、肺中金葡菌 Ｌ型免疫组化阳性率分别为６０５ ％ 、９３３ ％ 及６０ ％ ： 金葡萄 Ｌ 型 Ｄ Ｎ Ａ 探针原位杂交后在感染鼠子宫内膜、胎盘绒毛及子鼠肺组织中均发现有金葡菌 Ｄ Ｎ Ａ 表达， 阳性率分别为２０８ ％ 、３３３ ％ 、１６６ ％ ， 均高于对照组。提示 Ｌ 型金黄色葡萄球菌可通过垂直传播感染方式导致２ 代动物先天性感染， 这可能是引起妊娠异常结局的重要因素之一。
In this paper, Staphylococcus aureus and its stable L-type, in a variety of ways infected female Kunming mice, found that female pregnancy rate, childbirth per child and weight of offspring rats were lower than the control group, the difference was significant (P <001, P <001, P <005). On the infection of rat endometrium, placenta and offspring liver, lung and other tissues for immunohistochemistry and S. aureus L-digoxigenin nucleic acid probe in situ hybridization and found that Staphylococcus aureus L-infected female endometrium, Placenta and offspring liver, lung Staphylococcus aureus L-type immunohistochemical positive rates were 60 5%, 93 3% and 60%: gold grape L-type D N A probe in situ hybridization in mice infected uterus Staphylococcus aureus D N A was found in the endometrium, placenta villi and lung tissues of mice, the positive rates were 208%, 333% and 166%, respectively, which were higher than those in the control group. It is suggested that L-form Staphylococcus aureus can cause congenital infection of passage 2 animals by means of vertical transmission infection, which may be one of the important factors that cause abnormal pregnancy outcome.