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目的:探讨维生素E和维生素C联合治疗对120例新生儿缺氧缺血性脑病的临床疗效。方法:收集2007年4月～2011年5月在广西百色市右江民族医学院附属医院新生儿科住院治疗的新生儿缺氧缺血性脑病患者120例,按随机对照原则分为对照组(60例)和实验组(60例),对照组给予胞二磷胆碱及对症支持治疗,实验组在对照组的基础上加用维生素E和维生素C联合治疗,观察两组患者的临床疗效和不良反应。结果:实验组患者的临床有效率为73.3%,显著高于对照组的61.7%,两组间有效率具有统计学意义(P<0.05),两组患者药物不良反应发生率均较低。结论:维生素E和维生素C联合治疗新生儿缺氧缺血性脑病的临床疗效确切,安全性良好。
Objective: To investigate the clinical efficacy of combination of vitamin E and vitamin C on 120 neonates with hypoxic-ischemic encephalopathy. Methods: From April 2007 to May 2011, 120 cases of neonatal hypoxic-ischemic encephalopathy were treated in Department of Neonatology, Youjiang Medical College Affiliated Hospital, Baise City, Guangxi. The patients were divided into control group (60 Cases) and experimental group (60 cases). The control group was treated with citicoline and symptomatic supportive therapy. The experimental group was treated with vitamin E and vitamin C on the basis of the control group, and the clinical curative effect and adverse effects were observed reaction. Results: The clinical effective rate of the experimental group was 73.3%, significantly higher than that of the control group (61.7%). The effective rate between the two groups was statistically significant (P <0.05). The incidence of adverse drug reactions was lower in both groups. Conclusion: The combination of vitamin E and vitamin C in the treatment of neonatal hypoxic-ischemic encephalopathy is effective and safe.