间充质干细胞(MSCs)为具有多分化能力且能自我更新复制的骨髓间质细胞,已被多个临床试验证实具有很大的临床应用潜能,可被应用于组织损伤修复,如心肌梗死、脊柱及脑损伤、软骨及骨损伤等。而间充质干细胞“归巢”是其产生生物学效应的前提,因此进一步了解“归巢”机制可以为临床更有效的应用MSCs提供理论依据及有效的移植方法。 Mesenchymal stem cells (MSCs) are pluripotent mesenchymal cells capable of self-renewal and replication and have been proved to have great potential in clinical application by multiple clinical trials. MSCs can be used in tissue injury repair such as myocardial infarction, Spinal and brain injuries, cartilage and bone damage. The mesenchymal stem cells “homing ” is the prerequisite for their biological effects, so further understanding “homing ” mechanism can provide a theoretical basis for effective clinical application of MSCs and an effective transplantation method.