复方对乙酰氨基酚片中对乙酰氨基酚、阿斯匹林、咖啡因三种组分在零阶导数光谱中吸收峰重叠,本文用零交二阶导数结合联立方程组法,不经分离,直接同时测定。本法快速、准确、计算比较简单。三批模拟粉料与三批生产样品测定结果都比较满意,并与山东省药品标准的容量分析法相符合。 Compound paracetamol tablets paracetamol, aspirin, caffeine three components in the zero-order derivative of the absorption spectrum overlap, this article by second-order zero-crossing combined with simultaneous equations method without separation, direct Simultaneous determination. This method is fast, accurate and relatively easy to calculate. Three batches of simulated powder and three batches of samples were relatively satisfactory results, and consistent with the capacity of the Shandong Province Pharmaceutical Standards analysis method.