糖尿病 (DM)不但造成肾小球损害 ,也会造成肾小管损害。DM时肾小管病变可发生在肾小球病变之前、之后或同时发生。病变初期表现为肾小管基底膜增厚、小管数目增加及小管肥大 ,后期发生肾小管萎缩及间质纤维化。发病机制可能与高血糖等因素有关。治疗除了控制血糖、血压外 ,尚缺乏特异方法。 Diabetes mellitus (DM) not only causes glomerular damage, it can also cause tubular damage. Tubular renal tubular lesions can occur before, after, or simultaneously with glomerular lesions. Early lesions manifested as tubular basement membrane thickening, an increase in the number of tubules and tubular hypertrophy, renal tubular atrophy and interstitial fibrosis later. The pathogenesis may be related to factors such as hyperglycemia. In addition to controlling blood sugar, blood pressure, there is no specific method.