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目的 探讨癫 患者发作间期心血管自主神经功能与心率变异性（ＨＲＶ）的变化。方法 ５１例癫 患者根据标准心血管自主神经功能试验结果分为阳性（ＡＮＦＴ＋）组及阴性（ＡＮＦＴ－）组，与正常对照组３６例对比，进行ＨＲＶ分析。结果 癫 患者发作间期心血管自主神经功能异常率为４５．１％，且病程越长异常率越高。癫 患者在ＨＲＶ时域分析及非线性定量分析指标上均较对照组降低，且以 ＡＮＦＴ＋组患者最明显。ＨＲＶ直方图、散点图亦有特征性改变，以ＡＮＦＴ＋组患者最为显著。结论 癫 患者发作间期心血管自主神经功能存在紊乱现象，这种现象可能与癫 患者的猝死发生有关，ＨＲＶ是测定这一变化的敏感方法。
Objective To investigate the changes of cardiovascular autonomic nerve function and heart rate variability (HRV) in patients with epilepsy. Methods Fifty-one patients with epilepsy were divided into positive (ANFT +) group and negative (ANFT-) group according to the results of standard cardiovascular autonomic nervous function test. HRV analysis was performed in 36 epileptic patients compared with normal control group. Results Epilepsy patients interictal cardiovascular autonomic dysfunction rate was 45.1%, and the longer the duration of the higher the abnormal rate. Epilepsy patients in the HRV time-domain analysis and non-linear quantitative analysis indicators were lower than the control group, and ANFT + group was the most obvious. HRV histogram, scatter plot also have characteristic changes, the most significant ANFT + group of patients. Conclusions There is a disorder of cardiovascular autonomic function in epileptic patients during interictal episodes. This phenomenon may be related to the sudden death in epileptic patients. HRV is a sensitive method to measure this change.