目的探讨中药消肿乳糜清片剂对小鼠毛细血管通透性及网状内皮系统(RES)吞噬功能的影响。方法小鼠分组灌胃给药,尾静脉注射伊文斯兰后取腹腔液测光密度值,尾静脉注射印度墨后眼眶静脉取血测碳清指数k值。结果与对照组相比,消肿乳糜清片剂可明显降低小鼠毛细血管通透性,大、中、小剂量组OD值分别为0.466、0.626和0.771,碳廓清速率也明显增高,K值分别达到0.0357、0.0285和0.0226(P<0.01及P<0.05)。结论该药具有明显的消肿、降低毛细血管通透性、激活并增强网状内皮系统吞噬功能的作用,对缺氧损伤的淋巴管内皮细胞具有显著的保护作用。 Objective To investigate the effect of Xiaomei Chingqing Tablet on the capillary permeability and the phagocytic function of reticuloendothelial system in mice. Methods Mice were intragastrically administrated by intragastric administration. After intravesical injection of Evans blue, the peritoneal fluid optical density was measured. The orbital venous blood was taken from the tail vein to measure the carbon index (k). Results Compared with the control group, the detumescent chylomicrons could obviously reduce the capillary permeability in mice. The OD values ​​of the medium, small and medium dose groups were 0.466, 0.626 and 0.771 respectively, and the carbon clearance rate was also significantly increased. The K value 0.0357, 0.0285 and 0.0226 respectively (P <0.01 and P <0.05). Conclusion The drug has obvious swelling, reducing capillary permeability, activating and enhancing phagocytic function of reticuloendothelial system, and has a significant protective effect on lymphatic endothelial cells injured by hypoxia.