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目的:探讨腺样体免疫状况与分泌性中耳炎(SOM)的相关性。方法:采用VltrasentitiveTMSP免疫组织化学法检测反复发作的SOM伴腺样体增生者46例(反复发作组)及发作次数≤3次者30例(对照组)腺样体组织中CD45Ro、CD20、PCNA及BCL2的表达。结果:反复发作组腺样体组织中CD45Ro、CD20、PCNA及BCL2的表达明显高于对照组,其差异均有统计学意义(P<0.05或P<0.01)。结论:反复发作的SOM患儿腺样体中淋巴细胞活性增高,处于增殖期细胞增多,致使腺样体增生、肥大,同时局部免疫增强,加重了SOM。因此,对于SOM患儿应及早行腺样体切除术。
Objective: To investigate the relationship between adenoid immune status and secretory otitis media (SOM). Methods: VltrasentitiveTM SP immunohistochemical method was used to detect the CD45Ro, CD20, PCNA in 30 cases (control group) of adenoid tissues of 46 patients with recurrent SOM with adenoid hyperplasia (recurrent group) and with less than 3 times of recurrent attack BCL2 expression. Results: The expressions of CD45Ro, CD20, PCNA and BCL2 in the adenoid tissue were significantly higher than those in the control group (P <0.05 or P <0.01). CONCLUSIONS: In the recurrent SOM, the lymphocyte activity of adenoids is increased, and cells in proliferative phase are increased, resulting in hyperplasia and hypertrophy of adenoid and local immunity, which aggravates SOM. Therefore, children with SOM should be treated with adenoidectomy.