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目的:评价酞咪哌啶酮与抗结核药物联用治疗肺结核患者抗结核分枝杆菌的疗效及对患者生活质量的影响。方法:选取2014年3月—2016年8月间收治的肺结核患者74例,采用随机数表法将其分为对照组37例和观察组37例;对照组患者给予以利福平(R)、链霉素(S)、吡嗪酰胺(P)、异烟肼(H)治疗,观察组患者在对照组基础上加用酞咪哌啶酮治疗;评价两组患者临床治疗后的总有效率和治疗前后患者生活质量的评分值变化情况。结果:观察组患者治疗后的总有效率为91.89%高于对照组为62.16%(P<0.05);观察组患者治疗后的生活质量评分值高于对照组(P<0.05)。结论:采用酞咪哌啶酮与抗结核药物联用治疗肺结核患者抗结核分枝杆菌的疗效较为显著,优于常规抗结核药物的疗效,并能迅速提高患者的生活质量水平。
Objective: To evaluate the efficacy and safety of thalidomide combined with antituberculosis drugs in the treatment of Mycobacterium tuberculosis in patients with pulmonary tuberculosis. Methods: Totally 74 patients with tuberculosis who were admitted between March 2014 and August 2016 were selected and divided into control group (37 cases) and observation group (37 cases) by random number table method. Patients in the control group were treated with rifampin (R) , Streptomycin (S), pyrazinamide (P) and isoniazid (H). The patients in the observation group were treated with thalidomide on the basis of the control group. The patients in both groups were evaluated after treatment Efficiency and quality of life before and after treatment scores score changes. Results: The total effective rate after treatment in the observation group was 91.89% higher than that in the control group (62.16%, P <0.05). The quality of life score of the observation group was higher than that of the control group (P <0.05). Conclusion: The combination of thalidomide and anti-tuberculosis drugs in the treatment of patients with tuberculosis is more effective than anti-TB drugs, which is superior to the conventional anti-tuberculosis drugs and can rapidly improve the quality of life of patients.