所有外周原始神经外胚叶肿瘤(pPNET)家族成员,如Ewing肉瘤、骨的神经外胚层瘤、外周神经上皮瘤和Askin瘤都具有相类似的组织学形态及免疫表型特征(如在纤维背景下,增殖的小及中等大小圆细胞CD99免疫组化染色弥漫强阳性)和共同的细胞遗传学异常(如累及EWS基因和转录因子的小鼠成红细胞病毒转换序列的非随机易位)。虽然结合临床资料、形态学 All members of the peripheral primitive neuroectodermal tumor (pPNET) family, such as Ewing’s sarcoma, bone-derived neuroectodermal tumor, peripheral neuroepithelioma, and Askin’s tumor, have similar histological features and immunophenotypic features (eg, , Diffusely strong positive for proliferating small- and medium-sized round cells CD99 immunohistochemical staining) and common cytogenetic abnormalities such as non-random translocations of mouse erythroid-virus conversion sequences involving EWS genes and transcription factors. Although combined with clinical data, morphology