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目的:研究拉贝洛尔(labetalol,LBT)在nano-Fe3O4与多壁碳纳米管(Multi-walled carbon nanotubes,MWCNTs)复合修饰玻碳电极(nano-Fe3O4-MWCNTs/GCE)上的电化学行为及电化学动力学性质,建立LBT电化学定量测定方法。方法:循环伏安法(Cyclic Voltammetry,CV),计时电流法(Chronoamperometry,CA),方波伏安法(Square Wave Voltammetry,SWV)以及电化学交流阻抗谱(EIS)。结果:在nano-Fe3O4-MWCNTs/GCE上LBT发生了一受扩散控制的不可逆电化学氧化过程。考查了实验条件对LBT伏安行为的影响,测定了LBT在nano-Fe3O4-MWCNTs/GCE上的电极反应过程动力学参数。用SWV法测得LBT氧化峰电流与其浓度在1.0#10-5$1.0#10-3mol.L-1呈线性关系,检出限(S/N=3)为1.0#10-5mol.L-1。并用本方法对市售LBT片进行了电化学定量测定,RSD在0.4%～0.9%之间,加标回收率在99.70%～103.0%之间。结论:nano-Fe3O4-MWCNTs/GCE对LBT电化学氧化具有良好的催化作用,该方法可用于市售LBT片中LBT含量的电化学定量测定。
OBJECTIVE: To study the electrochemical behavior of labetalol (LBT) on nano-Fe3O4-MWCNTs / GCE with multi-walled carbon nanotubes (MWCNTs) And electrochemical kinetic properties, the establishment of LBT electrochemical quantitative determination method. Methods: Cyclic voltammetry (CV), chronoamperometry (CA), square wave voltammetry (SWV) and electrochemical impedance spectroscopy (EIS) were performed. RESULTS: An irreversible electrochemical oxidation of diffusion-controlled LBT occurred at the nano-Fe3O4-MWCNTs / GCE. The influence of experimental conditions on the voltammetric behavior of LBT was investigated. The kinetic parameters of the electrode reaction of LBT on nano-Fe3O4-MWCNTs / GCE were measured. The oxidation peak current of LBT measured by SWV showed a linear relationship with the concentration of 1.0 # 10-5 $ 1.0 # 10-3mol.L-1. The detection limit (S / N = 3) was 1.0 # 10-5mol.L-1 . The LBT tablets were electrochemically determined by this method. The RSD was between 0.4% and 0.9% and the recoveries were between 99.70% and 103.0%. CONCLUSION: The nano-Fe3O4-MWCNTs / GCE has a good catalytic effect on the LBT electrochemical oxidation. This method can be used for the electrochemical quantitative determination of LBT in commercial LBT tablets.