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以H＋－K＋－ATP酶（质子泵）抑制剂洛赛克（losec）静脉注射治疗上消化道出血患者40例，有效率为92．5％，与对照组有效率70％相比较，差异有显著性（P＜0．05）。洛赛克对上消化道出血的止血效果显著，止血作用迅速而持久，但加大剂量并不能使疗效呈比例增强。推荐首日剂量80mg，以后每日40mg较为合适。病因不同，其疗效也不一致。疗效高低依次为急性胃粘膜病变，十二指肠溃疡，糜烂型胃炎，胃溃疡；而对胃癌、肝硬化所致食管胃底静脉曲张破裂出血疗效较差，洛赛克不宜作为首选药物。
40 patients were treated with intravenous injection of H + -K + -ATPase (proton pump) inhibitor Losec in upper gastrointestinal bleeding, the effective rate was 92.5%. Compared with the control group, the effective rate was 70% Significance (P <0.05). Losec’s hemostatic effect on upper gastrointestinal bleeding is significant, rapid and long-lasting hemostatic effect, but increased dose does not make the proportion of enhanced efficacy. Recommended first dose 80mg, 40mg daily after more appropriate. Etiology is different, its efficacy is inconsistent. The order of curative effect is acute gastric mucosal lesion, duodenal ulcer, erosive gastritis and gastric ulcer; while it is less effective in the treatment of gastric cancer and cirrhosis due to rupture of esophagogastric varices. Losec should not be the first choice drug.