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目的:探讨云南白药联合西咪替丁治疗新生儿消化道出血的疗效。方法:奉节县人民医院住院的新生儿消化道出血患儿61例,随机分为治疗组31例和对照组30例。两组患儿均积极治疗原发疾病,同时禁食、鼻饲胃管、冰冷生理盐水洗胃,建立静脉通道补液,维生素K1止血,出血多者给予成分输血。治疗组在此基础上加用云南白药0.1 g冷盐水胃管注入胃内或者口服,每8 h 1次,西咪替丁10～15 mg/(kg.d)加入5%GS 20 mL中静脉滴注,连用3～5 d。结果:治疗组总有效率93.5%,对照组总有效率70.0%,两组比较差异有统计学意义(P<0.05)。结论:云南白药联合西咪替丁治疗新生儿消化道出血简单方便,安全有效,价格低廉,值得临床推广应用。
Objective: To investigate the efficacy of Yunnan Baiyao combined with cimetidine in the treatment of neonatal gastrointestinal bleeding. Methods: 61 cases of neonates with gastrointestinal bleeding admitted to Fengjie County People’s Hospital were randomly divided into treatment group (n = 31) and control group (n = 30). Both groups of children were active treatment of primary disease, fasting, nasogastric tube, cold saline gastric lavage, the establishment of intravenous access rehydration, vitamin K hemostasis, bleeding and more to give component transfusion. On the basis of this treatment, the treatment group was given Yunnan Baiyao 0.1 g cold saline gastric tube for oral administration, once every 8 hours, and cimetidine 10-15 mg / (kg.d) by adding 5% GS 20 mL medium vein Instillation, used in conjunction 3 ~ 5 d. Results: The total effective rate was 93.5% in the treatment group and 70.0% in the control group, with significant difference between the two groups (P <0.05). Conclusion: Yunnanbaiyao combined with cimetidine treatment of neonatal gastrointestinal bleeding is simple and convenient, safe and effective, cheap, worthy of clinical promotion and application.