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目的:研究和监测结核分枝杆菌不同药物浓度下耐药情况,为临床合理用药提供依据。方法:采用绝对浓度间接法,对利福喷丁、异烟肼、对氨基水杨酸、链霉素、吡嗪酰胺、乙胺丁醇、利福平、丁胺卡那、帕司烟肼、丙硫异烟胺、卷曲霉素、氧氟沙星12种药物的药敏试验。结果:223例肺结核患者痰分枝杆菌标本中,总耐药率为93.72%、其中初治患者为92.54%,复治为95.51%;单耐药率为10.31%;耐多药率为37.22%,初治为28.36%,复治为50.56%;广泛耐药率8.07%,约占耐多药的21.69%。结论:结核分枝杆菌培养在不同浓度下进行结核药敏试验,可以科学、合理地指导临床用药。
Objective: To study and monitor the drug resistance of Mycobacterium tuberculosis under different concentrations of drugs, and provide the basis for clinical rational drug use. Methods: The absolute concentration of indirect method, the rifapentine, isoniazid, p-aminosalicylic acid, streptomycin, pyrazinamide, ethambutol, rifampin, amikacin, , Prothiocarbamide, capreomycin, ofloxacin 12 kinds of drug susceptibility testing. Results: The total drug resistance rate was 93.72% in 223 cases of sputum mycobacterium tuberculosis, of which 92.54% were newly diagnosed, 95.51% were retreated, the single drug resistance rate was 10.31%, the multidrug resistance rate was 37.22% , The initial treatment was 28.36%, retreatment was 50.56%; the rate of extensive resistance was 8.07%, accounting for 21.69% of MDR. Conclusion: Mycobacterium tuberculosis culture in different concentrations of tuberculosis susceptibility testing, scientific and reasonable guidance of clinical medication.