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Fragile X (Fra (X)) syndrome is the most frequent cause of inherited mentalretardation, and it is associated with the fragile site at Xq27.3. In 1991, the FMR1(fragile X mental retardation 1) gene was cloned in the vicinity of this site. The muationand abnormal expression of FMR1 are the direct causes of Fra(X) syndrome. The cDNA
Fragile X (Fra (X)) syndrome is the most frequent cause of inherited mental retardation, and it is associated with the fragile site at Xq27.3. In 1991, the FMR1 (fragile X mental retardation 1) gene was cloned in the vicinity of this site. The muationand abnormal expression of FMR1 are the direct causes of Fra (X) syndrome. The cDNA