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合成 3,4,5-三羟基苯甲酸与苯三酚-[1,2,3]加Zncl_2于热POCl_3中缩合即得本品[DE 2501443]。药理作用本品是一种新的思维增强剂。动物实验表明,本品能激活神经元的氧和葡萄糖的代谢,同时能对抗由于短暂局部缺血引起的胺类神经传递的缺损,它也是一种自由基的有效清除剂。采用二种简单的小鼠记忆力和记忆障碍的模型,即探查活动的习惯性试验以及对抗莨菪胺引起的遗忘症的被动躲避试验,研究了本品的作用。在第一只模型中,以本品腹
Synthesis of 3,4,5-trihydroxybenzoic acid and pyrogallol - [1,2,3] plus Zncl_2 condensation in the heat POCl_3 This product [DE 2501443]. Pharmacological effects This product is a new thinking enhancer. Animal experiments show that this product can activate the oxygen metabolism of neurons and glucose, but also against short-term ischemia caused by amine neurotransmission defects, it is also a free radical scavenger. Two simple models of memory and memory impairment in mice were used, that is, the habitual test of exploration activity and the passive avoidance test of amnesia caused by scopolamine to study the effect of this product. In the first model, with this product belly