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目的通过分析免疫缺陷隐球菌病的临床特点,提高临床医师对本病的认识。方法回顾性收集2001年1月~2013年3月南京军区南京总医院确诊的免疫缺陷隐球菌病病例40例。分析其临床特点、治疗、预后,并得出结论。结果 40例患者2例因体检发现肺部占位就诊,其余38例均因出现临床症状就诊,其中最常见的为发热23例(57.5%),头痛14例(35.0%),恶心、呕吐10例(25.0%),咳嗽7例(17.5%);经治疗完全或部分缓解15例(37.5%),进展3例(7.5%),死亡22例(55.0%)。结论免疫缺陷隐球菌病病情重,死亡率高,应早诊断、规范治疗。
Objective By analyzing the clinical features of immunodeficiency cryptococcosis, clinicians to improve awareness of the disease. Methods Retrospectively collected 40 cases of cryptococcal immunodeficiency diagnosed in Nanjing General Hospital of Nanjing Military Command from January 2001 to March 2013. Analyze its clinical features, treatment, prognosis, and draw conclusions. Results Forty patients were diagnosed as having pulmonary lesions by physical examination. The remaining 38 patients were treated by clinical symptoms. Among them, 23 (57.5%) were fever, 14 (35.0%) had headache, nausea and vomiting (25.0%) and cough in 7 cases (17.5%). After treatment, 15 cases (37.5%) were completely or partially relieved, 3 cases (7.5%) were progressed, and 22 patients died (55.0%). Conclusion Cryptococcosis of immunodeficiency disease with severe illness and high mortality rate should be diagnosed and regulated early.