应用正交设计法[L_(16)(4~5)],观察烟酸、阿司匹林在不同水平合用时,对鹌鹑实验性动脉粥样硬化的影响,初步探讨了两药的剂量配比。结果表明:烟酸能明显抑制高脂饲料所致的血清总胆固醇(TC)、甘油三酯(TG)水平的增高,升高 HDL-C/TC 和 HDL_2-C/HDL_3-C 比值,同时降低动脉壁丙二醛(MDA)、总胆固醇(TC)、胆固醇酶(CE)含量 Orthogonal design method [L_ (16) (4 ~ 5)] was used to observe the effect of nicotinic acid and aspirin on the experimental atherosclerosis in quails at different levels. The dose proportion of the two drugs was preliminarily discussed. The results showed that nicotinic acid could significantly inhibit the increase of serum total cholesterol (TC) and triglyceride (TG), increase the ratio of HDL-C / TC and HDL_2-C / HDL_3-C The contents of malondialdehyde (MDA), total cholesterol (TC) and cholesterol (CE) in artery wall were measured