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目的通过对O型孕妇血清中血型抗体效价的测定,旨在了解异常IgG类血型抗体效价与新生儿溶血病(HDN)之间的关系。方法采用微柱凝胶法分别对1422例O型血孕妇血清中IgG抗A(B)水平进行测定。并对其产后进行新生儿溶血病的检测。结果母亲IgG抗体效价1:512,ABO-HDN患病率为100%;IgG效价1:256,ABO-HDN患病率为92.4%;IgG效价1:128,ABO-HDN患病率为88.3%;IgG效价1:64,ABO-HDN患病率为56.2%。各组间新生儿溶血病发病率差异有统计学意义(P<0.01),且随效价增高而增加。结论 O型孕妇孕前IgG抗体效价的检测对ABO-HDN有一定的预见性。
Objective To determine the relationship between the antibody titer of abnormal IgG type blood group and hemolytic disease of neonates (HDN) by measuring the blood group antibody titers in O pregnant women. Methods The levels of IgG anti-A (B) in sera of 1422 O-pregnant women were measured by microcolumn gel method. And postpartum neonatal hemolytic disease detection. Results The prevalence of ABO-HDN was 100% in maternal IgG antibody titer 1: 512, the prevalence of ABO-HDN was 92.4% in IgG titer 1: 256, the prevalence of IgG titer 1: 128 and ABO-HDN Was 88.3%. IgG titer was 1: 64, and the prevalence of ABO-HDN was 56.2%. The incidence of hemolytic disease among newborns was statistically significant (P <0.01), and increased with the increase of titer. Conclusion The detection of IgG antibody titer before pregnancy in O-pregnant women has certain predictive value for ABO-HDN.